Role of GOLPH3 in regulating client enzymes levels and glycosphingolipids synthesis 

Scientific illustration

Scientific illustration showing how GOLPH3 promotes lactosylceramide synthase (LCS) retention in the Golgi by mediating its retrograde transport from trans- to medial Golgi cisternae. LCS retention favors biosynthesis of glycosphingolipids (GSLs), which enhance signaling through the growth factor receptor tyrosine kinase (RTK) promoting cell growth. Illustration made for Somersault18:24 and published in Palm W. EMBO Journal. 2021.